Systemic sclerosis (SSc) is a multisystem rheumatic disease characterized by Stock Saddle Pads vascular dysfunction, autoimmune abnormalities, and progressive organ fibrosis.A series of studies in SSc patients and fibrotic models suggest that immune cells, fibroblasts, and endothelial cells participate in inflammation and aberrant tissue repair.Fur
Functional adaptation of cortical interneurons to attenuated activity is subtype-specific
Functional neuronal homeostasis has been studied in a variety of model systems and contexts.Many studies have shown that there are a number of changes that can be activated within individual cells or networks in order to compensate for perturbations or changes in levels of activity.Dissociating the cell autonomous from the network-mediated events h
In Situ Skin Friction Capacity Modeling with Advanced Neuro-Fuzzy Optimized by Metaheuristic Algorithms
Developing new optimization algorithms and data mining has improved traditional engineering structural analysis models (meaning basically swarm-based solutions).Additionally, an accurate quantification of in situ friction capacity (ISFC) of driven piles is of paramount importance in design/construction of geotechnical infrastructures.A number of st
Case Report: Treatment of Alectinib in NSCLC With Brain Metastasis Patient Refractory to Radiotherapy After Resistance to Crizotinib
BackgroundBrain metastasis is the most common form of tumor recurrence after resistance to crizotinib in patients with anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC).The treatment of brain metastasis in patients with ALK-positive NSCLC requires a multidisciplinary approach, including AEG IKE64450FB Electric Induction H
Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1
The highly mutated Shadow Box BA.2.86, with over 30 spike protein mutations in comparison to Omicron BA.2 and XBB.1.5 variants, has raised concerns about its potential to evade COVID-19 vaccination or prior SARS-CoV-2 infection-elicited immunity.In this study, we employ a live SARS-CoV-2 neutralization assay to compare the neutralization evasion ab